The lentivirus-hACE2 C57BL/6J mouse model of SARS-CoV-2 infection shares many cytokine signatures with those seen in human COVID-19 patients; IL-2, IL-10, IL-6, TNFα, IL-4, IL-1β, IFNγ and CSF3 signatures were found in SARS-CoV-2-infected lentivirus-hACE2 transduced C57BL/6J mice on day 2 post infection, and elevated levels of these cytokines are found in human COVID-19 patients [95, 96]. The gene discussed is IL1B; the disease is infection.