In this study, for understanding the correlation of EMT-related protein expression and the clinicopathologic features of CRC in Taiwan, we analyzed the expression of 8 EMT-related proteins (E-cadherin, β-catenin, claudin-1, CD44, N-cadherin, fibronectin, vimentin, S100A4) by immunohistochemistry assay. The gene discussed is CD44; the disease is colorectal carcinoma.