In our immunohistochemical analysis, vimentin expression is negative in most of the CRC specimens, but is aberrantly expressed in one case of signet-ring cell carcinoma (Fig 2), but in one comprehensive immunohistochemical research of primary signet-ring cell carcinoma in the stomach and colorectum from Japan [21], none of the 42 signet-ring cell carcinomas (30 gastric and 12 colorectal) express vimentin. The gene discussed is VIM; the disease is signet ring cell carcinoma.