This study revealed that the effect of ALK4 haplodeficiency on inflammation response in post-MI stage was mainly attributed to the following aspects: (1) reducing the recruitment of inflammatory cells, (2) reducing the secreting of classical-MФ(M1), (3) promoting the secreting of alternative-MФ(M2), (4) alleviating the pacing-induced ventricular arrhythmias. The gene discussed is ACVR1B; the disease is Ventricular arrhythmia.