In our previous studies, we identified ABCA7 rs3764650 and SORL1 rs1784933 as being associated with the risk of AD in Han Chinese individuals in Taiwan [7, 21], the association between BIN1 rs744373 and AD was reported in Asian populations [8], but the effect of these AD risk genes on the rate of cognitive decline is not clear. This evidence concerns the gene BIN1 and Alzheimer disease.