Previous studies have also shown that two SORL1 polymorphisms (rs3824968-A allele and rs2282649-T allele) were related to decreased cerebrospinal fluid (CSF) concentrations of Aβ42 and Aβ40 [39], the rs2070045-G allele was associated with increased CSF tau and more hippocampal atrophy [40], and SORL1 rs11218343 was associated with cognitive performance [41]. Here, MAPT is linked to hippocampal atrophy.