After adjusting for sex and education years, similar results showed that the APOE ε4 allele was significantly associated with an earlier mean change of −2.10 years in the age at midpoint of cognitive decline, the G allele in ABCA7 rs3764650 was significantly associated with an earlier mean change of −1.74 years, and the T allele in SORL1 rs3737529 was significantly associated with a later mean change of 2.65 years. The gene discussed is SORL1; the disease is Mental deterioration.