MTOR and diabetes mellitus: Notwithstanding our preliminary studies have also demonstrated that behavioural or morphological, glutamate and neurotransmitter changes in DD rats are similar to those observed in vitro simulated DD conditions and indicated that the hippocampal neuron autophagy which is activated by glutamate receptor2 (GluR2)/mammalian target of rapamycin (mTOR) signal pathway is of great importance for pathogenesis of diabetes‐related depression.19, 20