Next, exosomes were cocultured with colon cancer cells, and it was confirmed by quantitative reverse transcription‐polymerase chain reaction (qRT‐PCR) and western blot that iRGD‐exo‐si significantly downregulated the expression of CPT1A more efficiently than control‐exo‐si (exo‐si) (Fig. 5A,B). This evidence concerns the gene CPT1A and colonic neoplasm.