Related to T cell responses, several depletion studies, in which loss of either CD4+, CD8+, or both T cell subsets together, have demonstrated a worsened morbidity, mortality, or even foetal resorption in different ZIKV infection models, suggesting an important role for CD4+ and CD8+ T cells in the immune response to ZIKV [51]. Here, CD8A is linked to Zika virus infectious disease.