A recent investigationindicated that 7a inhibits the proliferation of 12 NSCLCcell lines in a dose-dependent manner and caused cell cycle arrestat the G0/G1 phase in NSCLC HCC827 and PC9 cells,consistent with studies indicating the role of SIRT6 in cell cycleregulation.16,70 Notably, it exhibited synergisticactivity with epidermal growth factor receptor tyrosine kinase inhibitors(EGFR-TKIs) in osimertinib-resistant HCC827 and PC9 cells and in patient-derivedprimary tumor cells. The gene discussed is SIRT6; the disease is neoplasm.