Indeed, SIRT6-deficientmice displayed alteration of glycolysis and genomic instability, ultimatelyleading to premature aging and shortened lifespan.6−8 In addition,SIRT6 deletion was associated with increased tumor aggressiveness,and later studies in human cancers identified mutations impairingSIRT6 activity.9 Conversely, recent studiesalso described SIRT6 as a tumor promoter, hence highlighting the context-dependentrole of this enzyme in cellular homeostasis.10,11. The gene discussed is SIRT6; the disease is cancer.