SIRT6 and cancer: In PDAC, Lin28bpromoter hyperacetylation is associated with c-Myc recruitment andconsequent augmentation of cancer progression and metastasis.68 Notably, c-Myc activity is antagonized by SIRT6,which represses the transcription of c-Myc and its target genes andleads to cell cycle arrest and inhibition of tumor growth.69,70