As already mentioned, CRC isa type of cancer characterized by heavy downregulation of SIRT6.8 Notably, 7c displayed dose-dependentreduction of H3K9Ac, H3K18Ac, and H3K56Ac levels in different CRCcell lines and antiproliferative effects associated with marked G0/G1 cell cycle arrest. The gene discussed is SIRT6; the disease is cancer.