Inaddition, SIRT6 expression is associated with higher reprogrammingefficiency of induced pluripotent stem cells (iPSCs).55 Given the increasing evidence supporting iPSC-based therapiesin the context of neurodegenerative diseases, SIRT6 activation mayrepresent a useful strategy to increase the success rate of thesetreatments. This evidence concerns the gene SIRT6 and neurodegenerative disease.