The downregulation of glycolyticgenes also acts as a tumor-suppressor pathway, since it suppressesthe Warburg effect.58 SIRT6 also regulatesfat metabolism by reducing LDL-cholesterol levels95 and triglyceride synthesis as well as promoting fatty-acidβ-oxidation,47 being a key playerin obesity prevention. This evidence concerns the gene SIRT6 and obesity due to melanocortin 4 receptor deficiency.