Arecent study indicated that SIRT6 is overexpressed in NSCLC cells,and its silencing determined activation of the p53/p21 pathway andconsequent inhibition of cell proliferation associated with cell cyclearrest and apoptosis.81 Conversely, anearlier study indicated that SIRT6 suppresses NSCLC proliferationthrough inhibition of Twist1 expression, a factor that facilitatesEMT and metastasis.82 The gene discussed is TP53; the disease is non-small cell lung carcinoma.