In PDAC, SIRT6 deficiency was associated withH3K9 and H3K56 hyperacetylation at the Lin28b promoter and poor patientprognosis; moreover, in a mouse model of pancreatic cancer, a SIRT6deficit led to increased tumor aggressiveness and metastasis.68 Given the severity of PDAC and the importantrole played by SIRT6 in this subset of tumors, targeting this pathwaythrough activation of SIRT6 may represent a successful approach forthis type of malignancy. The gene discussed is SIRT6; the disease is familial pancreatic carcinoma.