Unfortunately, ABPP in proteomes derivingfrom human cancer cell lines (PC3 and LNCaP) and mouse tissues (brain,liver, and testes) and ABPP-SILAC analysis on PC3 cells pointed outthat β-lactone 44 inhibited different serine hydrolasesincluding not only ABHD10 (IC50 value of about 100 nM)but also cathepsin A (CTSA), retinoid-inducible serine carboxypeptidase1 (SCPEP1), and acyl-CoA thioesterase 1/2 (ACOT1/2). The gene discussed is ACOT1; the disease is cancer.