NANP and malaria: We identified central NANP repeat region (NANP6)-targeted antibody dependent cellular phagocytosis (ADCP), binding of NANP6-targeting antibodies to the FcGRIIIa receptor, and anti-NANP6 IgG1 antibody titer as consistently predictive immune response measurements, with higher levels of each biomarker on day of challenge associated with individual-level protection after controlled malaria challenge.