As seen for plasma levels, Cxcl10 mRNA expression was also significantly reduced in gastrocnemius muscle of Tu‐Sk.T6Tg mice, compared with that in Tu‐CN mice, indicating a direct transcriptional regulation of Cxcl10 by SIRT6 in the context of tumour (Figure 7F). This evidence concerns the gene CXCL10 and neoplasm.