SIRT6 and neoplasm: While there was no significant change in WNT4 protein expression in gastrocnemius muscle of N.Tu‐CN and N.Tu‐Sk.T6Tg mice (Figure6C and Supporting Information, FigureS3A), in tumour‐bearing mice, SIRT6 over‐expression significantly reduced its expression in the muscle (Figure6D and Supporting Information, FigureS3B).