In line with these earlier reports, findings of our study suggest that although SIRT6 is over‐expressed in skeletal muscle, it improves plasma insulin level in our tumour model by probably modulating multiple targets, which include CXCL10, WNT4, and GLUT4 either in paracrine and/or autocrine manner to impede the cancer‐associated cachexia. Here, WNT4 is linked to neoplasm.