Cao et al.[20] identified integrated HPV genomes in the PD-L1 or PD-L2 loci in three cases from the TCGA Head and Neck Squamous Cell Carcinoma cohort and showed that these integration events correlated with elevated PD-L1 and PD-L2 expression. Here, PDCD1LG2 is linked to head and neck squamous cell carcinoma.