IDH1 and glioblastoma: According to gene transcription characteristics, GBM can be further classified into three subtypes: proneural [mutations on isocitrate dehydrogenase (IDH)-1 or tumor suppressor p53, and PDGFRA amplification], mesenchymal (mutation/deficiency of tumor suppressor NF1), and classical [EGFR amplification and CDKN2A (Ink4a/ARF) homozygous deletion] (Wang Q. et al., 2017).