In addition, DCs stayed in immature state and co-stimulatory molecules CD80 and CD86 were down-regulated owing to elevated secretion of VEGF from glioma cells (Malo et al., 2018b) expressing elevated metabolic enzymes (He et al., 2015), involving HK2, PHGDH (Wolf et al., 2011; Liu et al., 2013), HMGCR (Slawinska-Brych et al., 2014), COX-2 (Feng et al., 2017), nitric oxide (NO) metabolic regulation enzyme dimethylarginine dimethylaminohydrolase (Boult et al., 2011) and mutated IDH1 (Wang et al., 2014). Here, IDH1 is linked to glioma.