IL4R and central nervous system cancer: MDSCs account for more than 40% of glioma-infiltrating immune cells (Kamran et al., 2017) and expressed IL-4Rα, inducible nitric oxide synthase (iNOS) and ARG1 to inhibit the responses of glioma-killer T lymphocytes and NK cells (Kohanbash et al., 2013; Gielen et al., 2016), causing patients poor prognosis (Alban et al., 2018).