HMGCR and glioma: Controlling lipid metabolism resisted the invasion of gliomas, such as the application of phytol, retinol, and quercetin acting on FASN and SREBP1/2 (Facchini et al., 2018; Damiano et al., 2019), and the inhibition of acetyl-CoA carboxylase 1 and HMGCR by oleic acid and hydroxytyrosol (Priore et al., 2017).