Metabolic remodeling increased the level of metabolites from glioma cells to induce immune tolerance in the TME (Kesarwani et al., 2017), and drove the production of immunosuppressive factors such as arginase (ARG)-1, IL-10, and TGF-β (Guo et al., 2018; Figure 3A). The gene discussed is TGFB1; the disease is glioma.