As a special member of glioma TME, microglia are recruited to lesions through CX3CL1/CX3CR1 chemokine channel (Hambardzumyan et al., 2016), while peripheral monocyte-macrophages through the MCP-1/CCR2 channel (Vakilian et al., 2017). This evidence concerns the gene CX3CL1 and central nervous system cancer.