PTGES and central nervous system cancer: Prostaglandin E2 (PGE2) is another unsaturated fatty acid and known as an inducer of inflammation and pain, which was catalyzed from AA by cyclooxygenase (COX)-2 and prostaglandin E synthase (PGES) overexpressed in glioma cells, especially mesenchymal cells (Behnan et al., 2019).