GPX4 and glioma: To resist peroxidative damage, glioma cells initiate degradation of peroxidatively modified proteins through proteasome system (Nakayama et al., 2016), and abate ferroptosis by GSH, phospholipid hydroperoxidase glutathione peroxidase 4 (GPX4) and glutamate (Glu)/cystine (Cys) antiporter system Xc–.