In addition, DCs stayed in immature state and co-stimulatory molecules CD80 and CD86 were down-regulated owing to elevated secretion of VEGF from glioma cells (Malo et al., 2018b) expressing elevated metabolic enzymes (He et al., 2015), involving HK2, PHGDH (Wolf et al., 2011; Liu et al., 2013), HMGCR (Slawinska-Brych et al., 2014), COX-2 (Feng et al., 2017), nitric oxide (NO) metabolic regulation enzyme dimethylarginine dimethylaminohydrolase (Boult et al., 2011) and mutated IDH1 (Wang et al., 2014). Here, IDH1 is linked to central nervous system cancer.