The expression of CDH6, DPYSLE3, GJA1, IL15, and ACTA2 is also relevant to survival in many types of cancers, but its mechanism of action in CRC requires further study to explore its impact (Looyenga et al., 2013; Ji et al., 2018; Sun et al., 2018; Baek et al., 2019). The gene discussed is ACTA2; the disease is cancer.