C2CD3 and orofaciodigital syndrome: While several other centriolar proteins are required for centriole maturation, elongation, and uncapping (Hsiao et al., 2009; Schmidt et al., 2012; Burke et al., 2014; Kobayashi et al., 2014; Lu et al., 2015; Bhattacharyya et al., 2016), C2cd3 and Ofd1 have been a focus of study because of their association with the human ciliopathy Oral-facial-digital syndrome (OFD).