TGFB1 and hepatocellular carcinoma: Using this approach, scientists have demonstrated various factors that control 2D HCC migration including TGFβ1 (Fransvea et al., 2008; Ng et al., 2013), c-Myc (Zhao et al., 2013), YAP (Fitamant et al., 2015), goosecoid (Xue et al., 2014), actopaxin (Biname et al., 2008), and more recently miRNAs [miRNA-135a (Zeng et al., 2016), miRNA-338-3p (Chen et al., 2017), miRNA-1301 (Yang et al., 2017), miRNA-665 (Hu et al., 2018)].