RYR2 and lung adenocarcinoma: In a previous study on lung adenocarcinoma, several commonly mutated genes were predicted to be neoantigens of the major histocompatibility complex (MHC) Class I and Class II molecules (45), and some of these genes are also immune-related TMGs in RCC, including MUC16, ZFHX4, FAT3, TTN, and RYR2. Specifically, RYR2 and RYR3, the members of ryanodine receptors (RyR), have been reported to be associated with T cell activation (46).