Regarding the co-occurring pairs, UNC13C, NEB, and ZFHX4 were the major co-occurring genes in LCC (Figure 2C), whereas a majority of TMGs in RCC interacted with each other in a co-occurrence manner (Figure 2D), further proving the complicated tumorigeneses mechanism of RCC. The gene discussed is ZFHX4; the disease is leukoencephalopathy with calcifications and cysts.