As expected, most of these genes have higher mutation frequency in RCC compared to LCC, except for APC and TP53 (84% vs. 71%, 70% vs. 57% in LCC and RCC respectively, Figure S4), suggesting the potential dominant roles of APC and TP53 in LCC as previously shown (7). Here, TP53 is linked to leukoencephalopathy with calcifications and cysts.