Our finding rather supports the tumor-suppressive function of FcγRIIIA+ (CD16) TAN in primary tumor at least, although in many tumors a high intratumor density of neutrophils is known to be associated with a poor prognosis, probably in line with the tumor-supportive function of some subpopulations of TAN (N2 phenotype) (33, 34). This evidence concerns the gene FCGR3A and neoplasm.