Clinical analysis revealed that RP11 considerably upregulates the EMT-related transcription factor ZEB1 (98), triggers EMT and liver metastasis through the RP11/HNRNPA2B1/E3 ligase (Siah1and Fbxo45)/ZEB1 axis, and positively correlated with CRC stage in patients (17). Here, ZEB1 is linked to colorectal carcinoma.