In contrast, G-1 induces cell cycle arrest and inhibits prostate cancer cell growth through activation of ERK and it substantially reduces tumor size of cancer cell xenografted mice (24); G-1 decreases adrenocortical carcinoma cell growth in vivo and in vitro by inducing apoptosis (49); In addition, G-1 triggers apoptosis via ROS/ERK and inhibits NF-κB in colorectal cancer cells and suppresses the in vivo progression of colorectal cancer (21). This evidence concerns the gene NFKB1 and Familial prostate cancer.