In agreement with the studies mentioned above, our experiments showed that after exposure to G-1 for different times (0-48 h), although the total p65 level remained stable, there was significant reduction of phosphorylated-p65 kinase (Figure 5C), indicating that G-1 inhibits MCL cell proliferation through down regulating NF-κB signaling pathway. This evidence concerns the gene NFKB1 and mantle cell lymphoma.