ATM and mantle cell lymphoma: It is remarkable that low concentration of G-1 showed antitumoral activity, via pro-apoptosis and/or anti-proliferation functions, in MCL cell lines with either defective tumor suppressor gene (TP53 in Jeko-1 and Mino), DNA damage response gene (ATM in Granta-519), or cell-cycle checkpoint gene (p16 in Rec-1 and Granta-519) (52).