More importantly, we identified for the first time, new markers of the ECM pathway correlated with GBM IR-resistance, namely: ITGA2B, ITGA7, ITGB4, ITGB7, COL1A1, COL6A1, COL6A2, COL6A6, COL9A1, CD36, CHAD, COMP, GP1BA, GP5, GP6, HMMR, IBSP, LAMA1, LAMA3, LAMA4, LAMC2, LAMC3, SV2C, TNC, TNN, TNXB, VTN and VWF. The gene discussed is CHAD; the disease is glioblastoma.