In the present study, we developed a new lncRNA-mRNA signature (including lncRNA LINC00652 and its six coexpression genes, INSL3, NIPAL2, REN, RIMS2, RPRM, and SNAP91) in relapsed ALL patients based on WGCNA and LASSO analyses. The gene discussed is RPRM; the disease is acute lymphoblastic leukemia.