In the present study, we developed a new lncRNA-mRNA signature (including lncRNA LINC00652 and its six coexpression genes, INSL3, NIPAL2, REN, RIMS2, RPRM, and SNAP91) in relapsed ALL patients based on WGCNA and LASSO analyses. Here, INSL3 is linked to acute lymphoblastic leukemia.