ACE and diabetes mellitus: This situation is consistent with what has been described in previous studies,6,19 and could be explained by greater dysregulation of immune function and immunosenescence in older adults, as well as a higher prevalence of comorbidities.20 Certain comorbidities, such as hypertension, diabetes mellitus and chronic kidney disease, are treated with angiotensin converting enzyme inhibitors and angiotensin II receptor blockers, increasing the risk of severe disease and mortality.19 However, the role of the immune system in the pathophysiology of COVID-19 in this age group is still under study.