Furthermore, a previous study of 61 men and women with heart failure by Asselin et al. showed the involvement of BMI, medication status, blood pressure, blood linoleic acid, HDL-C, total bilirubin, reduced glutathione/oxidized glutathione ratio (GSH/GSSG ratio), glucose, alkaline phosphatase, and myeloperoxidase as determinants of plasma 4HNE-P and TBARS levels [14]. This evidence concerns the gene MPO and heart failure.