In addition, in the experimental model of arsenite-induced neuronal cell death that was shown to be associated with various neurodegenerative diseases such as Alzheimer's and Parkinson's, as well as amyotrophic lateral sclerosis (ALS), it was shown that the loss of neurons is caused by the accumulation of ROS and characteristic ferroptotic events, including mitochondrial VDAC-related pathways [114]. Here, VDAC1 is linked to amyotrophic lateral sclerosis.