OPA1 and myocardial infarction: Thus, in the present study, the hypothesis that Opa1-related mitophagy inhibits mitochondrial fission and oxidative stress through a mechanism involving the activation of the MAPK/ERK pathway was tested using control and Opa1-overexpressing H9C2 cardiomyocytes challenged with H2O2 to model myocardial infarction in vitro.