The top 10 signaling pathways are as follows: inflammatory bowel disease (IBD), rheumatoid arthritis, TNF signaling pathway, T cell receptor signaling pathway, cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, JAK/STAT signaling pathway, FoxO signaling pathway, HIF-1 signaling pathway, and insulin resistance (Figure 1(f)). The gene discussed is INS; the disease is rheumatoid arthritis.