Further examinations, including dual acridine orange/ethidium bromide and Annexin V-FITC/PI staining, flow cytometric analysis, cell cycle analysis, caspase-3 colorimetric assay, and initiator caspase immunoblotting were indicated that the selected extracts promote apoptosis through the activation of caspase-9 and caspase-3 in lung and breast cancer cell lines. The gene discussed is ANXA5; the disease is breast carcinoma.