In prenatally androgenized (PNA) PCOS-like mice, the GABA neuron axon inputs and GABAergic post-synaptic currents to GnRH neurons were increased, causing hyperactive GnRH impulses (Moore et al., 2015; Coutinho and Kauffman, 2019). Here, GNRH1 is linked to polycystic ovary syndrome.