Insulin resistance has been positively associated with BIP, MDD, SCZ, and cognitive defects (Kullmann et al., 2016; Agarwal et al., 2020; Cuperfain et al., 2020; Zou et al., 2020), reflecting roles of insulin in energy metabolism and dopamine release in the central nervous system, contributing to memory and learning. This evidence concerns the gene INS and Cognitive impairment.