In human and murine glioblastoma/glioma, differentially expressed let-7 miRNAs are signaling molecules that induce microglial inflammatory cytokine release, modulate antigen presentation, and attenuate cell migration in a TLR7-dependent manner (Buonfiglioli et al., 2019; Song et al., 2020). This evidence concerns the gene TLR7 and central nervous system cancer.