CFHR5 and Nephropathy: The classic example was identified in Greek Cypriot patients with C3GN (often called CFHR5 nephropathy) that results from a mutant FHR5 protein encoded by a CFHR5 gene with an internal duplication of exons 2 and 3 (FHR51,2-FHR5) (Gale et al., 2010).