For the 72-hour Pb exposure (Figure 6A), the subnetwork predicted the following: activation of Mpp5a (membrane protein, palmitoylated 5a) and Cldn5a (claudin 5a), suggesting that this treatment might affect epithelium integrity; increased activity of Chmp1a and Bmi1a; increased activity of Ccnd1 (cyclin-D1) and cell proliferation; decreased activity of Picalma; decreased activity of Fezf2 (FEZ family zinc finger 2) upstream of neuron differentiation; and decreased activity of Vangl2 (VANGL planar cell polarity protein 2) upstream of hydrocephaly. The gene discussed is CCND1; the disease is Hydrocephalus.