This finding is consistent with previous reports on cyclophosphamide-induced alterations in gut microbiota (26–30) and may result from cyclophosphamide-induced immunodeficiency because the results of the present study indicated that transcription of the components of the intestinal immune network for immunoglobulin A (IgA) production, hematopoietic cell lineages, and platelet activation was downregulated in cyclophosphamide-injected rats. Here, CD79A is linked to immunodeficiency disease.