The protein level of NLRP3 inflammasome was further quantified by western blot, in which NLRP3, NF-κB, pro-caspase-1 and pro-IL-1β were dramatically increased in BM-MNCs of ND AML patients, while they were hardly detected in BM-MNCs of controls (Figure 1A, Supplementary Figure 1E). The gene discussed is NLRP3; the disease is acute myeloid leukemia.