TLR7 and systemic lupus erythematosus: To elucidate the effect of EPA on the progression of SLE, we first induced lupus in wild-type FVB/N mice using imiquimod (IMQ), a TLR7 agonist, and prophylactically fed the mice a diet supplemented with 5% EPA or 5% palmitate as a control to match caloric intake (Figure 1A and Table S3).