To further assess the effect of EPA on autoimmunity in the setting of chronic spontaneous lupus, we employed C57BL/6Jlpr/lpr (B6lpr/lpr) mice, which carry a mutation in the apoptosis-inducing receptor gene Fas and develop lupus manifestations as early as 8 week-old (25) (Figure 3A). Here, FAS is linked to systemic lupus erythematosus.