Under this condition, EPA supplementation attenuated the IMQ-induced deposition of IgG and C3 in the kidneys and suppressed the abundance of serum autoantibodies that are typical lupus pathologies, however, total IgG and IgM levels in serum were unchanged (Figures 1D, E), indicating that EPA ameliorates autoimmunity but not general antibody production. This evidence concerns the gene C3 and systemic lupus erythematosus.