P. gingivalis LPS may induce diabetic renal inflammation, such as glomerulosclerosis and tubulitis with infiltration of Mac-1/podoplanin-positive macrophages, via glomerular overexpression of vascular cell adhesion molecule-1 (VCAM-1) and E-selectin (Kajiwara et al., 2021). This evidence concerns the gene VCAM1 and glomerulosclerosis.