CFTR and cystic fibrosis: Although CF nowadays remains an incurable disease, the identification of the defective CFTR gene in 1989 (Riordan et al., 1989; Rommens et al., 1989) has prompted significant advances in the development of molecular therapies aimed at addressing the underlying cellular defect (De Boeck and Amaral, 2016; Veit et al., 2016).