Based on the heatmap abundance at the genus level in the current study, CREA/CREB/CREC enriched the relative abundance of Bacteroides, which has been recognized as a genus important for glucose tolerance in T2D (Munukka et al., 2012; Zhang et al., 2013; Candela et al., 2016; Yamaguchi et al., 2016; Lippert et al., 2017). Here, CREB1 is linked to type 2 diabetes mellitus.