Our present study showed that the down-regulation of Alix was significantly attenuated after the treatment with Memantine as an NMDA receptor antagonist in APP/PS1 mice and Aβ25–35 intracerebroventricular-injected rats, which further confirmed that Alix might remain closely tied to the NMDA-related pathology of AD. This evidence concerns the gene PDCD6IP and Alzheimer disease.