Both hypoxia and AD associate with energy metabolic deficiencies and oxidative stress, and cerebral microvessels from AD patients release thrombin, VEGF, angiopoietin-2 (Ang-2), MMPs as well as inflammatory proteins, which correspond to the hypoxic responses (Grammas and Ovase, 2001; Grammas et al., 2006). Here, ANGPT2 is linked to Alzheimer disease.