This promoted the generation of cytokines, like interleukin (IL6, IL1α, and IL1β), tumor necrosis factor α (TNFα), granulocyte-macrophage colony-stimulating factor, and macrophage inflammatory proteins, which stimulated AD pathogenesis (Manczak et al., 2009; Passos et al., 2009; Kaur et al., 2019). This evidence concerns the gene TNF and Alzheimer disease.