Hence, through studies on neuronal and astrocyte cell lines and in TgCRND8 mice, it has been claimed that targeting APP mRNA-5′UTR may be a potential strategy in limiting APP translation and attenuating AD pathogenesis (Bandyopadhyay et al., 2006b,c, 2010, 2013; Tucker et al., 2006; Bandyopadhyay and Rogers, 2014). This evidence concerns the gene APP and Alzheimer disease.