TREM2 and Alzheimer disease: This is essential for the microglial biosynthetic metabolism, while an altered TREM2 expression deregulates the morphological and functional responses of microglial autophagy and its response to Aβ, as detected using the 5xFAD mouse model and AD patients, as well as in bone marrow-derived macrophages and microglia (Ulland et al., 2017).