Moreover, arterial spin labeling MRI [measured in AβPPSWE/PS1ΔE9 (APP/PS1) transgenic mice model of AD] revealed that alteration in CBF, mainly at the frontoparietal cortex and thalamus regions rather than the hippocampus and entorhinal cortex, had a significant link with early AD and vulnerability to AD pathology (Guo et al., 2019). Here, APP is linked to Alzheimer disease.