This SPI1 encodes the transcription factor PU.1 that regulates the ABCA7, CD33, MS4A4A, MS4A6A, TREM2, TREML2 and TYROBP gene expression and controls the phagocytic activity of Aβ, seen through a genome-wide survival study in AD patients and controls from the International Genomics of Alzheimer’s Project Consortium (Huang et al., 2017). Here, SPI1 is linked to Alzheimer disease.