Restoring ADAM10 activity to control levels in HD mice, achieved by crossing R6/2 mice with heterozygous conditional ADAM10 knockout mice (CaMKIIα-Cre:Adam10Flox/+), restored the ADAM10/piccolo interaction and replenished SV stores (Cozzolino et al., 2021). The gene discussed is ADAM10; the disease is Huntington disease.