While Alzheimer disease (AD) is associated with reduced ADAM10 levels (Kuhn et al., 2010), thereby resulting in excess amyloidogenic processing of amyloid precursor protein, ADAM10 is hyperactive in the HD brain at both pre- and postsynaptic localizations (Cozzolino et al., 2021). The gene discussed is ADAM10; the disease is early-onset autosomal dominant Alzheimer disease.