Just two Slc16 genes are significantly upregulated in Slc16a13 knockout liver under conditions of diet-induced obesity: Slc16a1 and Slc16a11. Both genes encode pyruvate transporter and lactate transport is well characterized for SLC16A1/MCT1. The gene discussed is SLC16A1; the disease is obesity due to melanocortin 4 receptor deficiency.