This idea is supported by our gene expression analyses: whereas hepatic Slc16a13 expression is upregulated in the context of diet-induced obesity (Fig. 1b), Slc16a1 expression was not found to be induced by HFD- compared to NCD-feeding (Supplementary Fig. 10a). This evidence concerns the gene SLC16A1 and obesity due to melanocortin 4 receptor deficiency.