BBS1 and obesity due to melanocortin 4 receptor deficiency: Later, the results of studies on targeted disruption of the BBSome by deletion of the Bbs1 gene in the brain using Nestin-cre (NestinCre/Bbs1fl/fl) showed obesity in mice, and the obese phenotype was reproduced by ablation of Bbs1 in LepRb-expressing neurons, LRbCre/Bbs1fl/fl62.