Systemic ablation of ciliary genes from neurons using Syn1-cre led to hyperphagic-induced obesity, and the obesity phenotype of both Kif3a-Syn1-KO and Tg737-Syn1-KO mice was reproduced in POMC-specific Kif3a-KO (Kif3a-Pomc-KO) mice [9]. Here, POMC is linked to obesity due to melanocortin 4 receptor deficiency.