CLOCK and sleep disorder: The key point was that the average course of sleep problems was 4.45 ± 6.79 years, and that of thyroid nodule diseases was 3.53 ± 4.82 years, the subtracted value was positive, indicating sleep disorders may be involved in the occurrence of elderly thyroid malignancy through the high expressions of CLOCK and BMAL1, and low expression of CRY2.