MYC and neoplasm: Wnt signalling target gene c-MYC mRNA fold-changes were significantly higher in tumour cells compared with normal (p < 0.001) but did not significantly differ between treatment groups, although with a smaller mean fold-change in intravenous 3.2 (1.90–4.50 95% CI) versus oral 4.7 (4.50–8.20 95% CI) (Fig. 2f).