ALDH2 and Alzheimer disease: The ability of CD14+ monocytes to produce inflammatory cytokines in response to LPS stimulation did not differ by ADH1B polymorphism; however, we noticed that CD14+ monocytes from AD patients with the ALDH2*1/*2 genotype produced significantly lower amounts of TNF-α compared to those in AD patients with ALDH2*1/*1 on admission (Fig. 3A).