Finally, because many patients with MDD were using psychiatric medications during the study as part of their treatment [primarily antidepressants (36%) and anxiolytics (40%)] and recent research in our group has reported high plasma concentrations of antiinflammatory molecules (e.g., N-acylethanolamines) in patients with MDD and antidepressant treatment48, we investigated the effects of antidepressants and anxiolytics on G-CSF concentrations. Here, CSF3 is linked to major depressive disorder.