Further, a meta-analysis on data from 4190 cases from 15 sites involved in the Genetic Epidemiology of Parkinson’s Disease (GEO-PD) Consortium, including some of the previously cited studies, found higher REP1 scores (defined here as the sum of allele score, with each 259-, 261-, or 263-bp allele contributing 0, 1, or 2 points, respectively) to be associated with an earlier AAO (hazard ratio (HR) = 1.06; p = 0.01)21. This evidence concerns the gene CHM and Parkinson disease.