It has been illustrated that the complex formed by DEPDC1A and zinc finger protein 224 (ZNF224) inhibited the expression of zinc finger protein A20, weakening the inhibitory effect of A20 on degradation of inhibitor of NF-κB (I-κB), thus promoting the translocation of NF-κB into the nucleus to activate the expression of related genes, and ultimately playing an anti-apoptotic physiological role in bladder cancer [31]. The gene discussed is ZNF224; the disease is urinary bladder cancer.