One recent study showed that the activity of NLRP3 inflammasome is increased in atrial cardiomyocytes (CMs) from patients with AF.68 CM-specific knock-in mice expressing constitutively active NLRP3 (CM-KI) developed spontaneous premature atrial contractions, which were blunted by the NLRP3 inhibitor MCC950. Here, NLRP3 is linked to atrial fibrillation.