A heterozygous NLRP3 (Q705K) variant is associated with poor survival in patients with invasive CRC.153 The AIM2 gene contains a coding region frame-shift mutation caused by microsatellite instability in CRC.154,155 In addition, regression analysis has shown that AIM2 can promote the development of endometrial cancer.156. The gene discussed is NLRP3; the disease is colorectal carcinoma.