IL18 and colonic neoplasm: In the CRC model of intrasplenic injection of colon cancer cells, inflammasome-mediated IL-18 production is responsible for the suppression of tumor growth in the liver.129 However, another study showed that NLRP3-mediated IL-1β secretion promotes the dissemination of colon cancer cells.141 In a carcinogen-induced tumor model, NLRP3 promotes metastasis by suppressing natural killer cell activity.142